Sox 6 (SOX6, SOX-6, SRY Sex Determining Region Y Box 6, SRY (Sex Determining Region Y)-box 6, HSSOX 6, HSSOX6, SRY-box 6, SRY Box Containing Gene 6, Transcription Factor SOX6, Transcription Factor SOX-6)

Supplier:

United States Biological

Cat no: S5364-23G

Sox 6 (SOX6, SOX-6, SRY Sex Determining Region Y Box 6, SRY (Sex Determining Region Y)-box 6, HSSOX 6, HSSOX6, SRY-box 6, SRY Box Containing Gene 6, Transcription Factor SOX6, Transcription Factor SOX-6)

SOX proteins bind to DNA in a sequence specific manner and have a tissue specific expression. They play a vital role in transcriptional regulation during embryonic development, cell differentiation, chondrogenesis and cell fate determination. SOX6 consists of a C-terminal HMG-box DNA-binding domain and N-terminal coiled-coil domain and forms homodimers. It plays a critical role in neurogenesis, cellular aggregation, muscle & cartilage formation and chondrogenesis. It is co-expressed with L-SOX5 and SOX9 during chondrogenesis and co-operates with SOX9 in the transactivation of Col2aI, a chondrocyte marker gene. It represses Fgf-3 expression during embryogenesis and is involved in maintaining physiological functions of skeletal and cardiac muscle.\n\nApplications:\nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1:500-1:1000\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

S5364-23G

Size

100ug

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Form

Supplied as a liquid in PBS, 0.02% sodium azide.

P Type

Pab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG

References

1. Akira Murakami et.al Nucleic Acids Res. 29(16): 3347

Additional Info

Recognizes human SOX6. Species Crossreactivity: mouse.

Read more on Supplier website

SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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