SOX17 (Transcription Factor SOX-17)

SOX17, also known as Transcription factor SOX-17, is, as the name suggests, a transcription factor and a probable transcriptional activator in the premeiotic germ cells. It belongs to the SRY-related HMG box family of transcription factors with a high-mobility group DNA-binding domain (HMG box) that plays a key role in embryogenesis and binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. SOX17 plays an essential role in cardiac mesoderm specification as well as in definitive hematopoiesis, maintaining fetal hematopoietic stem cells, hematopoiesis in the fetal liver and yolk sac. Along with beta-catenin it is known to cooperate in the regulation of transcription of endodermal genes. Defects in SOX17 are known to cause a severe defect in fetal hematopoiesis.\n\nApplications:\nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1-3ug/ml\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nMouse embryo brain lysate\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

S5364-45C

Size

100ug

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Ch/Bird, Prc

Form

Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

1. Kanai, Y. et al. J. Cell Biol. 133: 667-681 (1996). 2. Liu, Y. et al. Proc. Nat. Acad. Sci. 104: 3859-3864 (2007). 3. Sinner, D. et al. Development 131: 3069-3080 (2004).

Additional Info

Recognizes human SOX17. Species Crossreactivity: chicken, chimpanzee, mouse, opossum, porcine, rhesus monkey. Species sequence homology: rat.