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SOX9b, Control Peptide (SRY-box Containing Gene 9b, HMG Box Transcription Factor Sox9b)

SOX9b, Control Peptide (SRY-box Containing Gene 9b, HMG Box Transcription Factor Sox9b)

Cat no: 148973

Supplier: United States Biological
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Control Peptide for 151448. Sox9 is a transcription factor related to campomelic dysplasia and sex reversal in human patients. Earlier studies in zebrafish led to the identification of two homologues of mammalian sox9, sox9a and sox9b. The present study represents the first evaluation of expression patterns of zebrafish sox9b during early embryogenesis. Analyses reveal that sox9b transcripts are present throughout the life-cycle of the zebrafish, but exhibit tissue-specific distribution during embryogenesis. Zygotic expression of sox9b occurs in the anterolateral margins and the midline of the prospective dorsal neuroectoderm during late gastrulation. During early segmentation, the transcript is expressed in pairs of longitudinal bands in the prospective midbrain, hindbrain, and trunk, which identify the cranial and trunk neural crest progenitors. Neural crest cells cease expression of sox9b during migration, but some of their derivatives resume sox9b expression. Sox9b can serve as a marker for neural crest precursors.2 Source: Synthetic peptide corresponding to 13aa from near the internal region of SOX9b. Applications: Suitable for use in ELISA and Antibody Blocking. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: 148973
Applications: ELISA
Size: 100ug
Form: Supplied as a lyophilized powder. Reconstitute with 200ul sterile dH2O.
Purity: Purified
References: 1. Yan YL, Willoughby J, Liu D, Crump JG, Wilson C, Miller CT, Singer A, Kimmel C, Westerfield M, Postlethwait JH. A pair of Sox: distinct and overlapping functions of zebrafish sox9 co-orthologs in craniofacial and pectoral fin development. Development. 2005 Mar;132(5):1069-83. Epub 2005 Feb 2. 2. Dev Genes Evol. 2002 May;212(4):203-6. Epub 2002 Apr 18.: Zebrafish sox9b is an early neural crest marker., Li M, Zhao C, Wang Y, Zhao Z, Meng A.

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