SPAG8, CT (SPAG8, Sperm-associated antigen 8, HSD-1, Sperm membrane protein 1, Sperm membrane protein BS-84) (PE)

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein encoded by this gene is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined.\n\nApplications:\nSuitable for use in Western Blot, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze R-Phycoerythrin conjugates. Light sensitive. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

042196-PE

Size

200ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to R-Phycoerythrin (R-PE).

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Wu, H., et al. FEBS Lett. 584(13):2807-2815(2010)\nLi, R., et al. Cell Biochem. Funct. 27(5):264-268(2009)\nCheng, G.Y., et al. Asian J. Androl. 9(1):23-29(2007)\nTang, X., et al. J. Mol. Med. 82(6):383-388(2004)\nHumphray, S.J., et al. Nature 429(6990):369-374(2004)

Additional Info

Human

Alternative Names

SPAG8, Sperm-associated antigen 8, HSD-1, Sperm membrane protein 1, Sperm membrane protein BS-84