Spectrin, alpha (Spectrin Non-erythroid alpha Chain, Alpha Fodrin, Alpha II Spectrin, FLJ44613, Spectrin alpha Non-erythrocytic 1, SPTAN1, SPTA2)

Alpha Fodrin is a member of the spectrin family of widely distributed filamentous proteins that form a supporting and organizing scaffold for cell membranes (1). Non-erythroid alpha spectrin, also called Alpha Fodrin, is a major cortical cytoskeletal protein that has been implicated in the establishment of specialized membrane- cytoskeletal domains in differentiating cells (2-3). Cleavage of Alpha Fodrin accompanies apoptosis, induced by activation via the CD3/T cell receptor complex, ligation of the Fas (CD95) molecule and other Fas-expressing cells, or treatment of cells with staurosporine, dexamethasone, or synthetic ceramide (4). The major products of the cleavage are amino-terminal (135kDa) and carboxy-terminal (150kDa and 120kDa) fragments. Antibodies against Alpha Fodrin are observed in diseases characterized by chronic apoptosis, and are valuable in the evaluation fo Sicca- and Sj

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SPECIFICATIONS

Catalog Number

S5379-96F

Size

100ul

Applications

ICC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA.

P Type

Mab

Purity

Supernatant

Isotype

IgG

References

1. Leto TL, et al. Mol Cell Biol. 8(1):1-9, 1988. 2. Simonovic M, et al. J Biol Chem. 281(45):34333-40, 2006. 3. DH Giebelhaus, et al. The Journal of Cell Biology 105:843-853,1987. 4. Martin SJ, et al. J Biol Chem. 270(12):6425-8, 1995. 5. Ulbricht K U, et al. Autoimmunity Reviews 2(2):109-113, 2003 \n6. Kahaly, G. J., et al. Clinical & Experimental Immunology 140:166-172(7), 2005.

Additional Info

Recognizes human Alpha Fodrin. Species Crossreactivity: Mouse and rat.