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SPFH2 (Erlin-2, Endoplasmic Reticulum Lipid Raft-associated Protein 2, Stomatin-prohibitin-flotillin-HflC/K Domain-containing Protein 2, SPFH Domain-containing Protein 2, C8orf2, ERLIN2, UNQ2441/PRO5003/PRO9924)

Cat no: S5402-01A

SPFH2 (Erlin-2, Endoplasmic Reticulum Lipid Raft-associated Protein 2, Stomatin-prohibitin-flotillin-HflC/K Domain-containing Protein 2, SPFH Domain-containing Protein 2, C8orf2, ERLIN2, UNQ2441/PRO5003/PRO9924)

Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway.\n\nApplications:\nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:2000\nWestern Blot: 0.3-1ug/ml, observed in human breast lysates and in lysates of breast cancer on ~43kD bands\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

S5402-01A

Size

100ug

Applications

ELISA, WB

Hosts

Goat

Reactivities

Hum, Rat

Form

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

References

1. Garcia MJ, Pole JC, Chin SF, Teschendorff A, Naderi A, Ozdag H, Vias M, Kranjac T, Subkhankulova T, Paish C, Ellis I, Brenton JD, Edwards PA, Caldas C. A 1 Mb minimal amplicon at 8p11-12 in breast cancer identifies new candidate oncogenes. Oncogene. 2005 Aug 4;24(33):5235-45.

Additional Info

Recognizes human ERLIN2. Species sequence homology: Rat.

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