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Products Sphingosine Kinase 1 Inhibitor Screening Assay Kit
| Catalogue number: | 700430 |
| Weight: | 0 |
| Form: | 96 Well |
| P type: | Assay Kits|Ceramides/Sphingolipids |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | Sphingosine kinase 1 (SPHK 1) and SPHK 2 phosphorylate D-erythro-sphingosine to yield sphingosine-1-phosphate (S1P). S1P exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. SPHK 1 is a potential therapeutic target for the control of cancer and inflammation Cayman's SPHK 1 Inhibitor Screening Assay Kit provides a fluorescence-based method for screening SPHK 1 inhibitors. The procedure requires only two easy steps, both performed in the same microplate. In the first step, human recombinant SPHK 1 phosphorylates D-erythro-sphingosine C-18. In the second step, ADP is converted to hydrogen peroxide (H2O2) which then reacts with ADHP in the presence of peroxidase to yield the fluorescent product resorufin. |
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