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SRPK1 (Serine/Threonine-protein Kinase SRPK1, Serine/Arginine-rich Protein-specific Kinase 1, SR-protein-specific Kinase 1, SFRS Protein Kinase 1)

Cat no: S6570-76B

SRPK1 (Serine/Threonine-protein Kinase SRPK1, Serine/Arginine-rich Protein-specific Kinase 1, SR-protein-specific Kinase 1, SFRS Protein Kinase 1)

SRPK1, an SRPK serine/threonine protein kinase, phosphorylates SR proteins (splicing factors) which are arranged in speckles in the nucleus during mitosis, and thereby the receptor affects spliceosome assembly and distribution. SRPK1 has also been found to modify the lamin B receptor, an integral protein of inner nuclear membrane. The SRPK1 gene is involved in cisplatin-induced cell killing and can therefore confer drug resistance (Schenk et al., 2001). SRPK1, along with SRPK2, have been identified as the cellular protein kinases mediating HBV core protein phosphorylation during viral infection and therefore represent important host cell targets for therapeutic intervention in HBV infection.\n\nApplications:\nSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nImmunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

S6570-76B

Size

50ug

Applications

ELISA, IHC, WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2.

P Type

Mab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG1,k

Additional Info

Recognizes human SRPK1.

Read more on Supplier website

SUPPLIER INFO

Applications

ELISA

Reactivities

Hum

More info

Applications

IF

Hosts

Mouse

More info

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, IHC, WB

Hosts

Mouse

More info

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

More info

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

More info

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