SSRP1 Polyclonal Antibody

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SPECIFICATIONS

Price

323.00 USD

Catalog Number

CAC08097

Size

100 micro g

Applications

IF, WB

Hosts

Rabbit

Conjugates

Unconj

Purity

Protein G purified, >95%

Target

SSRP1

Clonality

Polyclonal

Storage Temp

Aliquot and store at -20 degrees C. Minimize freezing and thawing.

Research Area

For research use only. Not for diagnostic procedures.

Shipping Temp

Blue ice

Additional Info

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63.

Alternative Names

FACT complex subunit SSRP1,Chromatin-specific transcription elongation factor 80 kDa subunit,Facilitates chromatin transcription complex 80 kD,SSRP1,FACT80