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SSX1, Recombinant, Human, aa1-188, His-Tag (Protein SSX1, CT5.1, SSRC)

Cat no: 137214

SSX1, Recombinant, Human, aa1-188, His-Tag (Protein SSX1, CT5.1, SSRC)

Protein SSX1 belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. SSX proteins are localized to the nucleus and expressed in testis and several types of cancers and, therefore, they are classified as C/T (cancer/testis) antigens. These proteins may function as transcriptional repressors. SSX1 genes have been involved in the t (X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are probably responsible for transforming activity. \n\nSource: \nRecombinant protein corresponding to human SSX1, fused to His-tag at N-terminal expressed in E.coli.\n\nMolecular Weight: \n~24.3kD (211aa)\n\nAA Sequence:\nMGSSHHHHHH SSGLVPRGSH MGSMNGDDTF AKRPRDDAKA SEKRSKAFDD IATYFSKKEW KKMKYSEKIS YVYMKRNYKA MTKLGFKVTL PPFMCNKQAT DFQGNDFDND HNRRIQVEHP QMTFGRLHRI IPKIMPKKPA EDENDSKGVS EASGPQNDGK QLHPPGKANI SEKINKRSGP KRGKHAWTHR LRERKQLVIY EEISDPEEDD E\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

137214

Size

50ug

Form

Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, 0.4M urea, 10% glycerol.

Purity

~85% (SDS-PAGE)

References

1. Crew A J., et al. (1995) EMBO J. 14:2333-2340. 2. Nilsson G., et al. (1999) Cancer Res. 59:3180-3184.

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