ST2, NT (Interleukin-1 Receptor-like 1, Protein ST2, IL1RL1, DER4, ST2, T1)

ST2 is a member of a superfamily containing the interleukin-1 receptor and the Toll-like receptors (TLRs). The TLRs are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. ST2 was originally identified as a protein whose production was stimulated by various proliferation-inducing agents such as PDGF and FGF. More recently, it has been shown to negatively regulate IL-1 receptor and Toll-like receptor (TLR) 4 signaling and to maintain endotoxin tolerance. It has been suggested that the inhibition of TLR4 signaling occurs through the association and sequestering of TLR adaptor molecules such as MyD88 and TIRAP.\n\nApplications:\nSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1-2ug/ml\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nMouse kidney cell lysate\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

S6606-50F

Size

50ug

Applications

ELISA, IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Form

Supplied as a liquid in PBS, 0.02% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Takeda,K. et al. Annu. Rev. Immunol. 21, 335 (2003). 2. Janeway, CA Jr. et al. Annu. Rev. Immunol. 20, 197 (2002). 3. Lanahan, A. et al. Mol Cell Biol. 12, 3919 (1992). 4. Sweet, MJ. et al. J. Immunol. 166, 6633 (2001). 5. Brint, EK. et al.. Nat. Immunol. 5, 373 (2004). 6. Liew, FY. et al. Immunol. Lett. 96, 27 (2005).

Additional Info

Recognizes human ST2. Species Crossreactivity: mouse.