STC2 is a secreted 32kD protein and has 34% sequence identity with STC1 and eel STC. The culture medium of cells expressing STC2 inhibited promoter activity of the sodium-phosphate cotransporter (NaPi-3) and also inhibited phosphate uptake by a kidney cell line. STC2 is phosphorylated by an ecto-protein casein kinase-2 strictly on serine residues and can inhibit phosphorylation of cell-surface proteins. It was suggested that phosphorylation of STCs may be an important means of regulating their activity in calcium and phosphate homeostasis.
Source:
Recombinant protein corresponding to STC2, fused to T7 tag at N-terminal expressed in E.coli.
Molecular Weight:
~34.7kD
Applications:
Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilution:
Optimal dilutions to be determined by the researcher.
Storage and Stability:
Aliquot to avoid repeated freezing and thawing and store at -70 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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