Stat 6, phosphorylated (Tyr641) (Signal Transducer And Activator Of Transcription 6, IL-4 Stat) (Biotin)

STAT6 is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins.\n\nApplications: \nSuitable for use in ELISA and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:1,000\nImmunohistochemistry: 1:50-1:100\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

S7972-40M-Biotin

Size

200ul

Applications

ELISA, IHC

Hosts

Rabbit

Reactivities

Hum

Conjugates

Biotin

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to Biotin.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1.Valineva, T., et al., J. Biol. Chem. 280(15):14989-14996 (2005). 2.Tang, X., et al., Proc. Natl. Acad. Sci. USA 102(14):5132-5137 (2005). 3.Heller, N.M., et al., Am. J. Respir. Cell Mol. Biol. 31(5):573-582 (2004). 4.Galka, E., et al., J. Surg. Res. 122(1):14-20 (2004). 5.Zhang, W.J., et al., Int. J. Oncol. 24(2):447-453 (2004).

Additional Info

Recognizes human STAT6 when phosphorylated at Tyr641.