STAT1 Antibody

Cat no: 251896

Supplier: ABBIOTEC

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Description
Additional Information

Signal transducer and activator of transcription 1-alpha/beta (STAT1) mediates signaling by interferons (IFNs). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a comple, Xenopus/Amphibian, termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. STAT1 is tyrosine- and serine-phosphorylated in response to type II IFN (IFN-gamma). STAT1 deficiency results in impaired immune response leading to severe mycobacterial and viral diseases. In the case of complete deficiency,Porcineatients can die of viral disease.

Catalogue number:	251896
Reactivities:	Human, Mouse, Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	P42224
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human STAT1.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 50% glycerol with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit Ig
Additional info:	Signal transducer and activator of transcription 1-alpha/beta; Transcription factor ISGF-3 components p91/p84; STAT1