Cell-permeable. A potent and selective inhibitor of Stat3 SH2 domain:pTyr interactions; also disrupts the binding of Stat3 to the IL-6R/gp130 peptide, GpYLPQTVNH? and induces antitumor effects in vitro.
Peptide Sequence: H-Phe-Ile-Ser-Lys-Glu-Arg-Glu-Arg-Ala-Ile-Leu-Ser-Thr-Lys-Pro-Pro-Gly-Thr-Phe-Leu-Leu-Arg-Phe-Ser-Glu-Ser-Ser-Lys-OH