Home  >  Products  >  STAT3, Phosphorylated (Tyr708), Control Peptide (Signal Transducer and Activator of Transcription 3, Acute-phase Response Factor, APRF)

STAT3, Phosphorylated (Tyr708), Control Peptide (Signal Transducer and Activator of Transcription 3, Acute-phase Response Factor, APRF)

Cat no: S7969-84S


Supplier: United States Biological
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Control Peptide for S7969-84C. Stat3 is a key signaling molecule for many cytokines and growth-factor receptors (1), and is required for murine fetal development (2). Additionally, Stat3 is constitutively activated in a number of human tumors (3,4) and possesses oncogenic potential (5) and anti-apoptotic activities (3). Stat3 is activated by phosphorylation at Tyr705, which induces dimerization, nuclear translocation and DNA binding (6,7). Transcriptional activation seems to be regulated by phosphorylation at Ser727 via the MAPK or mTOR pathway (8,9). Stat3 isoform expression appears to reflect biological function: the relative expression levels of Stat3a (86 kD) and Stat3b (79kD) depend on cell type, ligand exposure or maturation stage of the cells (10). It is notable that Stat3b lacks the serine phosphorylation site within the carboxy-terminal transcriptional activation domain (8). Source: Synthetic peptide corresponding to the zebrafish Stat-3 with phosphorylation on Tyr708 (VTQP-pY-LKT). Applications: Suitable for use in ELISA and Antibody Blocking. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: S7969-84S
Applications: ELISA
Size: 100ug
Form: Supplied as a liquid in PBS. Labeled with BSA.
Purity: Purified
References: (1) Heim, M.H. (1999) J. Recept. Signal Transduct. Res. 19, 75

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*

Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave