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Stearoyl CoA Desaturase 1 Inhibitor (4-(2-Chlorophenoxy)-N-(3-(3-methylcarbamoyl)phenyl)piperidine-1-carboxamide, SCD1 Inhibitor)

Stearoyl CoA Desaturase 1 Inhibitor (4-(2-Chlorophenoxy)-N-(3-(3-methylcarbamoyl)phenyl)piperidine-1-carboxamide, SCD1 Inhibitor)

Cat no: S7900-07

Supplier: United States Biological
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Cell-permeable. A potent and selective inhibitor of SCD1(stearoyl-CoA desaturase 1) (In vitro: IC50 = 37nM for hSCD1, < 4nM for mSCD1). Also exhibited in vivo efficacy with dose-dependent desaturation index lowering effect. SCD1 inhibition resulted in alterationsin macrophage membrane lipid composition and marked hypersensitivity to toll-like receptor 4 agonists. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: S7900-07
Size: 1mg
Form: Supplied as a crystalline solid. Reconstitute with DMSO (~180mg/ml)
Purity: ~98% (HPLC)
Alternative names: 4-(2-Chlorophenoxy)-N-(3-(3-methylcarbamoyl)phenyl)piperidine-1-carboxamide
References: Xin, Z., et al. (2008). Bioorg. Med. Chem.. Lett. 18, 4298- 4302.

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