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Stevioside hydrate (BRN 0077427, CCRIS 6116)

Cat no: 045317

Stevioside hydrate (BRN 0077427, CCRIS 6116)

Noncaloric natural sweetener, 300 times more potent than sucrose. \nAntidiabetic. Antihyperglycaemic and antihypoglycaemic. Potentiates insulin secretion. Enhances acetyl-CoA carboxylase (ACC) gene expression. Increases insulin sensitivity.. \nAntihypertensive. Ca2+ influx inhibitor. \nAnticancer compound. \nChemopreventive. \nAnti-inflammatory. IKKbeta, NF-kappaB and MAPK signaling inhibitor. Induces TNF-alpha, IL-1beta and nitric oxide release. \nImmunomodulator. Increasees phagocytic activity, haemagglutination antibody titre, delayed type hypersensitivity. Increased proliferation in LPS and Con A stimulated B and T cells. \nPeripheral micro-opioid receptors activator. Important for regulation of glucose homeostasis. \nAnti-atherosclerotic. \n \n\n\nStorage and Stability:\nShort-term Storage: +4 degrees C\nLong-term Storage: +4 degrees C\nStable for at least 2 years after receipt when stored at +4 degrees C.

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SPECIFICATIONS

Catalog Number

045317

Size

10mg

Purity

>95% (NMR)

References

Product Reference: \n?Letter to the editor: stevioside, a natural sweetening agent: C. Taylor; Am. J. Clin. Nutr. 22, 4 (1969)\n?Stevioside acts directly on pancreatic beta cells to secrete insulin: actions independent of cyclic adenosine monophosphate and adenosine triphosphate-sensitive K+-channel activity: P.B. Jeppesen, et al.; Metabolism 49, 208 (2000)\n?Inhibitory effect of stevioside on calcium influx to produce antihypertension: C.N. Lee, et al.; Planta Med. 67, 796 (2001)\n?Stevioside induces antihyperglycaemic, insulinotropic and glucagonostatic effects in vivo: studies in the diabetic Goto-Kakizaki (GK) rats: P.B. Jeppesen, et al.; Phytomedicine 9, 9 (2002)\n?Inhibitory effect of stevioside on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin: K. Yasukawa, et al.; Biol. Pharm. Bull. 25, 1488 (2002)\n?Antihyperglycemic and blood pressure-reducing effects of stevioside in the diabetic Goto-Kakizaki rat: P.B. Jeppesen, et al.; Metabolism 52, 372 (2003)\n?Antihyperglycemic effects of stevioside in type 2 diabetic subjects: S. Gregersen, et al.; Metabolism 53, 73 (2004)\n?Effects of stevioside on glucose transport activity in insulin-sensitive and insulin-resistant rat skeletal muscle: N. Lailerd, et al.; Metabolism 53, 101 (2004)\n?Mechanism of the hypoglycemic effect of stevioside, a glycoside of Stevia rebaudiana: T.H. Chen, et al.; Planta Med. 71, 108 (2005)\n?Anti-Inflammatory and Immunomodulatory Activities of Stevioside and Its Metabolite Steviol on THP-1 Cells: C. Boonkaewwan, et al.; J. Agric. Food Chem. 54, 785 (2006)\n?Stevioside improves pancreatic beta-cell function during glucotoxicity via regulation of acetyl-CoA carboxylase: J. Chen, et al.; Am. J. Physiol. Endocrinol. Metab. 292, E1906 (2007)\n?Immune up regulatory response of a non-caloric natural sweetener, stevioside: I. Sehar, et al.; Chem. Biol. Interact. 173, 115 (2008)\n?Stevioside and related compounds: therapeutic benefits beyond sweetness: V. Chatsudthipong & C. Muanprasat; Pharmacol. Ther. 121, 41 (2009) (Review)\n?Cancer preventive agents. Part 8: Chemopreventive effects of stevioside and related compounds: M. Takasaki, et al.; Bioorg. Med. Chem. 17, 600 (2009)\n?Stimulatory effect of stevioside on peripheral mu opioid receptors in animals: P.S. Yang, et al.; Neurosci. Lett. 454, 72 (2009)\n?Stevioside inhibits atherosclerosis by improving insulin signaling and antioxidant defense in obese insulin-resistant mice: B. Geeraert, et al.; Int. J. Obes. 34, 569 (2010)\n?Stevioside ameliorates high-fat diet-induced insulin resistance and adipose tissue inflammation by downregulating the NF-kappaB pathway: Z. Wang, et al.; BBRC 417, 1280 (2012)\n?Stevioside Suppressed Inflammatory Cytokine Secretion by Downregulation of NF-kappaB and MAPK Signaling Pathways in LPS-Stimulated RAW264.7 Cells: L. Fengyang, et al.; Inflammation 35, 1669 (2012)\n?

Alternative Names

BRN 0077427, CCRIS 6116

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