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Stichodactyla Toxin

Cat no: RTS-400

Stichodactyla Toxin

Stichodactyla Toxin (ShK). KvпїЅChannelпїЅBlocker

Stichodactyla toxin (ShK) is a peptidyl toxin originally isolated from the nematocyst of the sea anemone Stichodactyla helianthus

ShK blocks Kv1.3, Kv1.1, Kv1.4, and Kv1.6 at subnanomolar concentrations and Kv3.2 channels at 1000-fold higher concentration than that required to inhibit Kv1.3 channels. It has been shown to block Kv current in DRG neurons, to displace radioactive Dendrotoxin from brain synaptosomes and inhibit I125-Charybdotoxin binding to Jurkat T lymphocytes with an IC50 of 32 pM.

Evidence also suggests that native Kv currents in the central nervous system, which areпїЅpredominantly carried by Kv1.2 channels, are highly sensitive to this toxin.

A fluorescently labeled synthetic ShK is used to recognize and to sort Kv1.3 containing lymphocytes.

Alomone Labs is pleased to offer rStichodactyla (rShK), a recombinant peptide expressed in and extracted from E. coli and purified to homogeneity.

Ion Channel Modulators; K+пїЅChannel Blockers.

Prices direct from Alomone Labs Ltd.

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

RTS-400

Size

10 micro g

Purity

>98%

Concentration

150 pM - 25 nM

Shipping Temp

Room Temperature

Molecular Weight

4055 da

SUPPLIER INFO

Alomone Labs Ltd.

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