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Stimulating Gene 15, Recombinant, Human (ISG15, 15kD ubiquitin-like modifier GIP2, IFI15, Ubiquitin Cross-reactive Protein, UCRP)

Cat no: I7662-94E

Stimulating Gene 15, Recombinant, Human (ISG15, 15kD ubiquitin-like modifier GIP2, IFI15, Ubiquitin Cross-reactive Protein, UCRP)

The interferon-stimulated gene, 15 kD (ISG15) is an interferon regulated gene that is induced as a primary response to diverse microbial and cell stress stimuli, and encodes the founding member of the ubiquitin-like protein family. ISG15 shares several common properties with other ubiquitin-like molecules (UBLs), but its activity is tightly regulated by specific signaling pathways that have a role in innate immunity.\n\nMolecular Weight: 34kD (308 aa)\n\nSequence: MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ DMINEVDADG NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY ISAAELRHVM TNLGEKLTDE EVDEMIREAD IDGDGQVNYE EFVQMMTAKG SMGWDLTVKM LAGNEFQVSL SSSMSVSELK AQITQKIGVH AFQQRLAVHP SGVALQDRVP LASQGLGPGS TVLLVVDKCD EPLNILVRNN KGRSSTYEVR LTQTVAHLKQ QVSGLEGVQD DLFWLTFEGK PLEDQLPLGE YGLKPLSTVF MNLRLRGG\n\nApplications: \nSuitable for use in ELISA. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage, aliquot to avoid repeated freezing and thawing and freeze at -70 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 12 months.

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SPECIFICATIONS

Catalog Number

I7662-94E

Size

100ug

Applications

ELISA

Form

Supplied as a liquid in 20mM Tris pH8.0, 0.1M NaCl, 1mM DTT.

Purity

> 98% by SDS PAGE

References

Narasimhan J., et al. (2005) J Biol Chem. Jul 22; 280(29):27356-65.\nAndersen JB., et al. (2006) Cytokine Growth Factor Rev. Dec; 17(6):411-21

Alternative Names

GIP2, UCRP, IFI15

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