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SPECIFICATIONS
Price
323.00 USD
Catalog Number
CAC07485
Size
100 micro g
Applications
IHC, WB
Hosts
Rabbit
Conjugates
Unconj
Purity
Caprylic Acid Ammonium Sulfate Precipitation Purified
Target
STK24
Clonality
Polyclonal
Storage Temp
Aliquot and store at -20 degrees C. Minimize freezing and thawing.
Research Area
For research use only. Not for diagnostic procedures.
Shipping Temp
Blue ice
Additional Info
Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.
Alternative Names
Mammalian STE20-like protein kinase 3 Mammalian STE20-like protein kinase 3 N-terminal Mammalian STE20-like protein kinase 3 C-terminal STK24 MST3, STK3
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