Streptolysin O, Human, Plasma (SLO, ASLO)

Streptolysin O, isolated from human plasma. Streptolysin-O (SLO) is a bacterial protein that forms an alpha helix and is toxic to eukaryotic cells. Its toxic effect is due to the protein's ability to bind to cholesterol and form holes in the plasma membrane of cells. This ability can be utilized in the laboratory to create holes in the plasma membrane but not other membranes.\n\nStreptolysin is a hemolysin produced by group A streptococci. In an infected individual streptolysin O acts as a protein antigen, and the patient mounts an antibody response. A rise in anti-streptolysin O level begins about 1 week after infection and peaks 2-3 weeks later. In the absence of complications or reinfection, the anti-streptolysin O ASO titer will usually fall to preinfection levels within 6-12 months. Both clinical and laboratory findings should be correlated in reaching a diagnosis.??Streptococcal infections are caused by bacteria known as Streptococcus. There are several disease-causing strains of streptococci (groups A, B, C, D, and G), which are identified by their behavior, chemistry, and appearance. Each group causes specific types of infections and symptoms. These antibody tests are useful for group A streptococci. Group A streptococci are the most virulent species for humans and are the cause of strep throat, tonsillitis, wound and skin infections, blood infections (septicemia), scarlet fever, pneumonia, rheumatic fever, Sydenham's chorea (formerly called St. Vitus' dance), and glomerulonephritis.\n\nSupplied as a concentrate for research and diagnostic manufacturing.?\nRecertification: 2 years\n\npH: 7.0-7.2\n\nProtein:\n(same/more than) 3g/dL (Biuret)\n\nActivity:\n(same/more than)500 IU/mL (Beckman Array)\n\nReducing Agents:\nThe activity is significantly increased in the presence of reducing agents, 20mM cysteine or 10mM dithiothreitol.\n\nStorage and Stability:\nLyophilized powder stored dessicated at -20 degrees C. Stable for 12 months. After reconstitution, aliquot and store at -20 degrees C. SLO is readily oxidized in solution.

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