Streptozotocin (2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose, Streptozocin, STZ, NSC 85998, Antibiotic U9889, Zanosar)

Antibiotic Diabetogenic. Diabetes inducer. Induces diabetes mellitus in animal models through its toxic effects on pancreatic beta-cells Mutagenic.\n Potent alkylating agent. Potent DNA methylating agent Nitric oxide (NO) donor. Vasorelaxant. Cytotoxic to cells that express GLUT2 glucose transporter. O-GlcNAc-selective N-acetyl-beta-D-glucosaminidase (O-GlcNAcase) inhibitor. \nGenotoxic. Induces DNA damage. Produces DNA strand breaks. Cell death inducer.\n Antineoplastic. Anti-cancer agent used in chemotherapy. \nInduces cell cylce arrest at G2.\n\n\nStorage and Stability:\nShort-term Storage: +4 degrees C\nLong-term Storage: -20 degrees C\nStable for at least 2 years after receipt when stored at -20 degrees C.

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SPECIFICATIONS

Catalog Number

045318

Size

50mg

Purity

>98% (HPLC)

References

Product Reference: \n?Streptozotocin, a new antibacterial antibiotic: J.J. Vavra, et al.; Antibiot. Ann. 7, 230 (1959)\n?Studies on the diabetogenic action of Streptozotocin: N. Raketien, et al.; Cancer Chemother. Rep. 29, 91 (1963)\n?Mutagenic activity of Streptozotocin: S.M. Kolbye & M.S. Legator; Mutat. Res. 6, 387 (1968)\n?Alkylation of DNA in rat tissues following administration of streptozotocin: R.A. Bennett & A.E. Pegg; Cancer Res. 41, 2786 (1981)\n?Streptozotocin interactions with pancreatic beta cells and the induction of insulin-dependent diabetes: G.L. Wilson & E.H. Leiter; Curr. Top. Microbiol. Immunol. 156, 27 (1990) (Review)\n?Nitric oxide generation from streptozotocin: N.S. Kwon, et al.; FASEB J. 8, 529 (1994)\n?STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells: W.J. Schnedl, et al.; Diabetes 43, 1326 (1994)\n?Glucose stimulates protein modification by O-linked GlcNAc in pancreatic beta cells: linkage of O-linked GlcNAc to beta cell death: K. Liu, et al.; PNAS 97, 2820 (2000)\n?Chromosomal response of human lymphocytes to Streptozotocin: A.D. Bolzan & M.S. Bianchi; Mutat. Res. 503, 63 (2002)\n?Genotoxicity of streptozotocin: A.D. Bolzan & M.S. Bianchi; Mutat. Res. 512, 121 (2002) (Review)\n?Clastogenic effects of streptozotocin on human colon cancer cell lines with gene amplification: A.D. Bolzan & M.S. Bianchi; J. Environ. Pathol. Toxicol. Oncol. 22, 281 (2003)\n?Streptozotocin induces G2 arrest in skeletal muscle myoblasts and impairs muscle growth in vivo: A.P. Johnston, et al.; Am. J. Physiol. Cell Physiol. 292, C1033 (2007)\n?The mechanisms of alloxan- and streptozotocin-induced diabetes: S. Lenzen; Diabetologia 51, 216 (2008)\n?Mechanisms of toxic effect of streptozotocin on beta-cells in the islets of langerhans: V.B. Pisarev, et al.; Bull. Exp. Biol. Med. 148, 937 (2009)\n?The role of programmed cell death in streptozotocin-induced early diabetic nephropathy: W.H. Wu, et al.; J. Endocrinol. Invest. 34, e296 (2011)\n?

Alternative Names

2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose, Streptozocin, STZ, NSC 85998, Antibiotic U9889, Zanosar