Substance P (NK, Neurokinin)

Supplier:

United States Biological

Cat no: S8000-05B

Substance P (NK, Neurokinin)

Substance P occurs in nerve fibers of the central and peripheral nervous system and in endocrine cells of the gut. It stimulates smooth muscle contraction, gives rise to vasodilation and is involved in sensory functions. Substance P-containing tumors arising in the ileum are often associated with the carcinoid syndrome, characterized by flushing of the skin, diarrhea, bronchoconstriction and sudden drops in blood pressure. Substance P is commonly found in the midgut carcinoids and some of the symptoms may be related to this peptide. \n\nApplications:\nSutiable for use in Immunofluorescence and Immunohistochemistry. Other applications have not been tested. \n\nRecommended Dilutions: \nImmunohistochemistry: Frozen sections\nImmunofluorescence: 1:400-1:800 with overnight incubation at 4 degrees C.\nOptimal dilutions to be determined by the researcher.\n\nPositive Control: \nFrozen sections of rat colon\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

S8000-05B

Size

50ul

Applications

IF, IHC

Reactivities

Hum, Rat, Rabbit

Form

Supplied as a lyophilized powder. Reconstitute with 50ul sterile ddH2O. Dilute further with PBS, 1% BSA, 0.1% sodium azide.

P Type

Pab

Purity

Serum

Isotype

IgG

References

1. Hardebo JE et al. Origins of substance P- and calcitonin gene-related peptide-containing nerves in the internal carotid artery of rat. Neuroscience letters 101:39-45 (1989) 2. Witt M et al. Innervation of developing human taste buds. An immunihistochemical study. Histochem. Cell Bio 109 (3), 281-291 (1998) 3. Shabazi F et al: Primary structure, distribution, and effects on motility of CGRP in the intestine of the cod Gadus morhua. Am J Physiol 44, R19-R44 (1998). 4. G

Additional Info

Recognizes Substance P. Absorption with 10-100ug SP and NKA per ml diluted antiserum abolishes the staining while GRP and NKB do not. Species Crossreactivity: human, rat, rabbit and fish (cod).

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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