Home  >  Products  >  Succinyl-CoA Synthetase Subunit alpha (SCS-alpha, GALPHA, MTDPS9, Succinyl-CoA Ligase [GDP-forming] Subunit alpha Mitochondrial, SUCLA1, SUCLG1)
Succinyl-CoA Synthetase Subunit alpha (SCS-alpha, GALPHA, MTDPS9, Succinyl-CoA Ligase [GDP-forming] Subunit alpha Mitochondrial, SUCLA1, SUCLG1)

Succinyl-CoA Synthetase Subunit alpha (SCS-alpha, GALPHA, MTDPS9, Succinyl-CoA Ligase [GDP-forming] Subunit alpha Mitochondrial, SUCLA1, SUCLG1)

Cat no: S8008-72

Supplier: United States Biological
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Succinyl-CoA synthetase a subunit (SUCLG1) catalyzes the conversion of succinate to succinly- CoA and plays a key role in the citric acid cycle (1,2). Deficiency of this enzyme leads to a variety of diseases including fatal infantile lactic acidosis (3) and mitochondrial hepatoencephalomyopathy (4). Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Incubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4 degrees C with gentle shaking, overnight. Immunoprecipitation: 1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S8008-72
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 100ug/ml BSA, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by Protein A affinity chromatography.
Alternative names: Succinate-CoA Ligase, alpha Subunit, EC=6.2.1.4, FLJ21114, FLJ43513
References: (1) Johnson, J.D. et al. (1998) J Biol Chem 273, 27580-6. (2) Phillips, D. et al. (2009) Biochemistry 48, 7140-9. (3) Ostergaard, E. et al. (2007) Am J Hum Genet 81, 383-7. (4) Van Hove, J.L. et al. (2010) Pediatr Res 68, 159-64.
Additional info: Recognizes endogenous levels of total succinyl-CoA synthetase (a subunit). Species Crossreactivity: mouse, rat.

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