SULT1A3, Recombinant, Human (Sulfotransferase 1A3/1A4, ST1A3/ST1A4, Aryl Sulfotransferase 1A3/1A4, Catecholamine-sulfating Phenol Sulfotransferase, HAST3, M-PST, Monoamine-sulfating Phenol Sulfotransferase, Placental Estrogen Sulfotransferase, Sulfotransf

The human Catecholamine-Sulfating Phenol Sulfotransferase (CSPS) is the only sulfotransferase that catalyses the sulfation of catecholamines, in particular the neurotransmitter dopamine, with high activity. CSPS is required for stimulation by Mn2+ of the sulfating activity and expressed in the human intestine, brain, platelet and other tissues. In the brain it may play a role in regulating the levels of dopamine. It also serves as a detoxifying function in the intestine, where it may detoxify potentially lethal dietary monoamines.\n\nSource:\nRecombinant corresponding to aa1-295, with additional 3aa-GSH at N-terminal, from human CSPS, expressed in E.coli.\n\nMolecular Weight:\n~36.5kD\n\nStorage and Stability:\nAliquot to avoid repeated freezing and thawing and store at -70 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

S8022-03B4

Size

250ug

Form

Supplied as a liquid in 20mM HEPES, pH7.0, 10% glycerol.

Purity

~95% (SDS-PAGE)

References

1. Pai,T.G. et al. (2003) J. Biol. Chem. 278, 1525-1532. 2. Pai,T.G. et al. (2002) J. Biol. Chem. 277, 43813-43820. 3. Coughtrie, M.W.H. (2002) Pharmacogenomics J. 2, 297-308.