Sumanirole is a high affinity D2 receptor agonist (EC50 values are between 17 and 75 nM in cell-based assays). Sumanirole displays >200-fold selectivity for the D2 receptor against other dopamine receptor subtypes (Ki values are 9.0, 1940, >2190 and >7140 for D2, D3, D4 and D1 receptors respectively). Sumanirole exhibits anti-Parkinsonian activity similar to Ropinirole.
Form:
Off-White to Light Beige Solid
Melting Point:
206-208 degrees C (dec.)
Solubility:
DMSO, Methanol
Pfizer Compound
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