Surfactant protein A Antibody

Surfactant protein A (SP-A) is synthesized and secreted by lung epithelial cells. It belongs to group III of the family of C-type lectins and members of this group has overall structure consisting of multiple globular 'head' regions linked by triple-helical, collagen-like, strands. This group also includes SP-D and the serum proteins mannan-binding protein, conglutinin and collectin-43, all of which have been shown to bind to the C1q receptor found on a wide variety of cells. Both SP-D and SP-A have been shown to enhance o, Xenopus/Amphibian,ygen radical production by alveolar macrophages. The serum concentration is 45 ng/ml in healthy individuals. SP-A, in the presence of calcium ions, binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Genetic variations in SP-A are a cause of susceptibility to pulmonary fibrosis idiopathic (IPF). Pulmonary fibrosis is a lung disease characterized by shortness of breath, radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on biopsy. IPF results in acute lung injury with subsequent scarring and endstage lung disease.

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SPECIFICATIONS

Catalog Number

251280

Size

0.1 mg

Applications

IHC

Reactivities

Hum, Mouse, Bov, Prc, Rabbit

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

P Type

Rabbit Polyclonal Antibody

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the N-term human surfactant protein A.

Isotype

Rabbit Ig

Accession

Q8IWL2

Additional Info

SP-A; Pulmonary surfactant-associated glycoprotein A; Pulmonary surfactant-associated protein A1; SP-A1; PSP-A; PSP-A; PSPA; Alveolar proteinosis protein; 35 kDa pulmonary surfactant-associated protein; SFTPA1; SFTPA1B; PSAP; SFTP1; SFTPA