Home  >  Products  >  Survival Motor Neuron Domain-containing Protein 1, aa1-238, Recombinant, Human (SMNDC1, 30kD Splicing Factor SMNrp, Survival of Motor Neuron-related-splicing Factor 30, SPF30, SMN-related Protein, SMNR)
Survival Motor Neuron Domain-containing Protein 1, aa1-238, Recombinant, Human (SMNDC1, 30kD Splicing Factor SMNrp, Survival of Motor Neuron-related-splicing Factor 30, SPF30, SMN-related Protein, SMNR)

Survival Motor Neuron Domain-containing Protein 1, aa1-238, Recombinant, Human (SMNDC1, 30kD Splicing Factor SMNrp, Survival of Motor Neuron-related-splicing Factor 30, SPF30, SMN-related Protein, SMNR)

Cat no: S8495-75

Supplier: United States Biological
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SMNDC1 (survival motor neuron domain containing 1) is an essential splicing factor required for spliceosome assembly that belongs to the SMN family. It contains one Tudor domain with significant similarity to SMN (Survival Motor Neuron) and is expressed in skeletal muscle, pancreas and heart, localizing to Cajal bodies and nuclear speckles. Mutations in which are cause of autosomal recessive proximal spinal muscular atrophy. Source: Recombinant corresponding to human SMNDC1, fused to His-tag at N-terminus, expressed in E. coli. Molecular Weight: ~28.9kD Sequences of Amino Acids: MGSSHHHHHH SSGLVPRGSH MSEDLAKQLA SYKAQLQQVE AALSGNGENE DLLKLKKDLQ EVIELTKDLL STQPSETLAS SDSFASTQPT HSWKVGDKCM AVWSEDGQCY EAEIEEIDEE NGTAAITFAG YGNAEVTPLL NLKPVEEGRK AKEDSGNKPM SKKEMIAQQR EYKKKKALKK AQRIKELEQE REDQKVKWQQ FNNRAYSKNK KGQVKRSIFA SPESVTGKVG VGTCGIADKP MTQYQDTSKY NVRHLMPQ Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: S8495-75
Size: 50ug
Form: Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, 5mM DTT, 100mM sodium chloride, 20% glycerol.
Purity: ~90% (SDS-PAGE)
References: 1. Meister G., et al. (2001) EMBO J. 20:2304-2314 2. Talbot K., et al. (1998) Hum. Mol. Genet. 7:2149-2156

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