SYK (8C1A) Antibody

Cat no: 252775

Supplier: ABBIOTEC

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Description
Additional Information

SYK (Spleen tyrosine kinase), along with Zap-70, is a member of the Syk family of cytoplasmic tyrosine kinases, containing a dual SH2 domain separated by a linker region. In B cells, SYK couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through phosphorylation/activation of phospholipase C-gamma, when phosphorylated on Tyr-348 and Tyr-352. Phosphorylation on Tyr-323 creates a binding site for c-Cbl, which is a negative regulator of BCR-stimulated calcium signaling. Also transmits signals from other cell surface receptors including the T-cell receptor, CD74, Fc receptor and integrins. Abnormal constitutive SYK activity has been implicated in some hematopoietic malignancies.

Catalogue number:	252775
Reactivities:	Human
Applications:	Western Blot
Size:	0.1 ml
Accession:	P43405
Antigen:	Purified recombinant fragment of SYK(aa296-484) e, Xenopus/Amphibian,pressed in E. coli.
Format:	Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
P type:	Mouse Monoclonal Antibody
Isotype:	Mouse IgG1
Clonality:	8C1A3
Additional info:	SYK; Spleen Tyrosine Kinase; Tyrosine-protein kinase SYK