SYK Antibody

Cat no: 250530

Supplier: ABBIOTEC

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Description
Additional Information

SYK (Spleen tyrosine kinase), along with Zap-70, is a member of the Syk family of cytoplasmic tyrosine kinases that contain a dual SH2 domain separated by a linker region. In B cells, SYK couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through phosphorylation/activation of phospholipase C-gamma, when phosphorylated on Tyr-348 and Tyr-352. Phosphorylation on Tyr-323 creates a binding site for c-Cbl, which is a negative regulator of BCR-stimulated calcium signaling. Also transmits signals from other cell surface receptors including the T-cell receptor, CD74, Fc receptor, and integrins. Abnormal constitutive SYK activity has been implicated in some hematopoietic malignancies.

Catalogue number:	250530
Reactivities:	Human, Mouse, Bovine, Porcine, Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	P43405
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the center region of human SYK.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit IgG
Additional info:	SYK; Spleen Tyrosine Kinase; Tyrosine-protein kinase SYK