Synaptotagmin (SYT, DKFZp781D2042, P65, SVP65, Synaptotagmin I, SYT1, SYT-1, SytI, SYT2, SYT3)

Synaptotagmins are integral membrane proteins of synaptic vesicles that are thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin participates in triggering neurotransmitter release at the synapse. The first C2 domain mediates Ca(2+)-dependent phospholipid binding. The second C2 domain mediates interaction with Stonin 2. Synaptotagmin may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.\n\nApplications: \nSuitable for use in Immunohistochemistry and Immunocytochemistry. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

S9108-98A

Size

250ul

Applications

ICC, IHC

Hosts

Ch/Bird

Reactivities

Hum, Mouse

Form

PBS [pH7.2] containing 0.02% sodium azide

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Additional Info

Species Crossreactivity: Reacts with mouse Synaptotagmin. Other species have not been tested. Homology with human is 100% for the immunizing peptides.

Alternative Names

P65, SVP 65, SVP65, Synaptotagmin I, SYT 1, SYT, SYT1, SYTI