Synuclein (A19) Peptide

Alpha Synuclein is implicated in the regulation of dopamine release and transport. It is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). In the nervous system, alpha Synuclein is primarily located at presynaptic terminals and is found membrane bound in dopaminergic neurons. It can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies), including Parkinson's Disease. Alpha Synuclein induces fibrillization of microtubule associated protein tau and reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase 3 activation. Alpha synuclein is a protein phosphorylated predominantly on serine residues.

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SPECIFICATIONS

Catalog Number

BS1349P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide Synuclein (A19). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

P37840

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS1349 Synuclein (A19) pAb.

Alternative Names

Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP; pan Synuclein; NACP Non A-beta Component Of AD Amyloid PARK1 PARK4 PD1 SNCA Synuclein Alpha (Non A4 Component Of Amyloid Precursor