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Synuclein, alpha, Human, Western Blot Positive Control

Cat no: S9500-01S

Synuclein, alpha, Human, Western Blot Positive Control

Parkinson's disease (PD) is a common neurodegenerative disorder with a lifetime incidence of approximately 2 percent; the clinical manifestations of this neurodegenerativedisorder include resting tremor, muscular rigidity, bradykinesia,and postural instability. A relatively specific pathological featureaccompanying the neuronal degeneration is an intracytoplasmicinclusion body, known as the Lewy body. A mutation was identified in the -synuclein gene, which codesfor a presynaptic protein thought to be involved in neuronal plasticity, this mutation may cause a conformational change that renders -synuclein more prone to self aggregation and deposition in Lewy bodies, which finally leads to oxidative stress and misfolding of -synuclein. Parkin gene, mutations in this gene are reported in early autosomal-recessive form of PD, however these mutations do not degenerate Lewy bodies. The Parkin gene product (Parkin) is involved in protein degradation as a ubiquitin protein ligase, the known substrates of Parkin include Pael-R (Parkin-associated endothelin receptor-like receptor), Ubiquitination of Pael-R by Parkin leads to its degradation in the proteasome, however failure to ubiquitinate it leads to death of neuron. The synuclein exists in 3 isoform -syn (chrm 4q21), a 140aa protein, implicated in pathogenesis of PD and related neurodegenerative disorders, it is mainly expressed in brain specifically in neuronal cell bodies and synapses. The 134 aa b-syn (chrm 5q35) is homologous to 14kD bovine phosphoneuroprotein 14; SCNB has been shown to be highly expressed in the substantia nigra of the brain. Recently a new isoform termed g-synuclein (SNCG) or breast cancer gene 1 (BCG1) has been cloned (human 127 aa (chrm 10q23), rat/mouse 123 aa). Higher levels of expression of SNCG has been reported in advanced breast carcinomas. All three synuclein show ~40% identity.\n\nSource:\nHuman Alpha synuclein recombinant protein, an acidic neuronal protein of 140aa that has been implicated in the pathogenesis of Parkinson

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SPECIFICATIONS

Catalog Number

S9500-01S

Size

100ul

Applications

WB

Form

Supplied as a liquid in reduced SDS-PAGE sample buffer.

Purity

(same/more than) 95% by SDS-PAGE

References

Kim. J et al (1997) Mo. Cells 7, 78; Paik, S.R et al (1997) Arch Biochem. Biophys, 344, 325, Jakes. R et al. 1994, FEBS Lett. 345, 27.\n

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Applications

ELISA

Hosts

Rabbit

Reactivities

Hum

Conjugates

Biotin

More info

Applications

ELISA, IHC

Hosts

Rabbit

Reactivities

Hum

Conjugates

Biotin

More info

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

Conjugates

Biotin

More info
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