Synuclein, alpha, Recombinant, Human (NACP)

alpha-Synuclein (amino acids 1-140), an acidic neuronal protein of 140 amino acids, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. a-synuclein has been suggested to be implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells. Moreover, recent studies have shown that a-synuclein has chaperone activity and that this activity is lost upon removing its C-terminal acidic tail (amino acids 96-140).\n\nDescription: \nRecombinant Human a-Synuclein produced in E.Coli is a single,non-glycosylated polypeptide chain having a molecular mass of 14,460 Dalton. Recombinant Human a-Synuclein is purified by proprietary chromatographic techniques.\n\nSequence: \nMDVFMKGLSK/ AKEGVVAAAE/ KTKQGVAEAA/ GKTKEGVLYV/ GSKTKEGVVH/GVATVAEKTK/ EQVTNVGGAV/VTGVTAVAQK/TVEGAGSIAA/ ATGFVKKDQL/ GKNEEGAPQE/ GILEDMPVDP/DNEAYEMPSE/EGYQDYEPEA\n\nStability: \nStore at 4 degrees C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degrees C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles.

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SPECIFICATIONS

Catalog Number

S9500-39A

Size

20ug

Form

Supplied as a liquid in 20mM Tris-HCl, pH 7.5, 0.1M NaCl and 1mM MgCl2.

Purity

(same/more than) 95% as determined by RP-HPLC, anion-exchange FPLC and/or reducing and non-reducing SDS-PAGE Silver Stained gel.

References

1. Ventral tegmental area dopamine neurons are resistant to human mutant alpha-synuclein overexpression.\n\nNeurobiol Dis 2006 Jun 26;\n\n2. Novel covalent modifications of alpha-synuclein during the recovery from proteasomal dysfunction.\n\nBiochem Biophys Res Commun 2006 Aug 11;346(4):1312-1319\n\n3. Intranigral Dopamine Toxicity and alpha-Synuclein Response in Rats.\n\nNeurochem Res 2006 Jun 28;\n\n4. alpha-Synuclein Can Function as an Antioxidant Preventing Oxidation of Unsaturated Lipid in Vesicles.\n\nBiochemistry 2006 Jul 4;45(26):8135-42\n\n5. Chaperone-like activities of alpha-synuclein: alpha-Synuclein assists enzyme activities of esterases.\n\nBiochem Biophys Res Commun 2006 Aug 11;346(4):1142-9\n\n6. Levels of alpha-synuclein mRNA in sporadic Parkinson disease patients.\n\nMov Disord 2006 Jun 22;