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Synuclein-(beta) (S118) pAb

Synuclein-(beta) (S118) pAb

Cat no: BS1348

Supplier: Bioworld Technology, Inc.
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The synuclein family members, including (alpha)-synuclein (also designated NACP for non-(beta) amyloid component) and (beta)-synuclein, are predominantly expressed in the brain and are speculated to be involved in synaptic regulation and neuronal plasticity. (alpha)-synuclein is localized to neuronal cell bodies and synapses. (alpha)-synuclein was first identified as a component of Alzheimer's disease amyloid plaques. Abnormal platelet function in Alzheimer's disease has been demonstrated. During megakaryocytic differentiation (alpha)-synuclein was found to be upregulated, while (beta)-synuclein is downregulated, indicating that coordinate expression of synucleins may be important during hematopoetic cell differentiation. A mutant form of (alpha)-synuclein has been found in patients with early onset Parkinson's disease.
Catalogue number: BS1348
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunofluorescence, Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: Q16143
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 82-140 of Human Synuclein-(beta).
Species: Synuclein (beta) (S118) pAb detects endogenous levels of Synuclein (beta) protein.
Molecular weight: ~ 14 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: SNCB; BETA-SYNUCLEIN
Additional info: For research use only, not for use in diagnostic procedure.

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