T-box 1 (Tbx1, T-box family of transcription factors)

Supplier:

United States Biological

Cat no: T1848-24

T-box 1 (Tbx1, T-box family of transcription factors)

T-box 1 (or Tbx1) is a member of a gene family characterized by the presence of a region known as the T-box, which is a DNA-binding domain homologous to a region found in the protein product of the T gene. The T, or Brachyury, gene was first identified as being responsible for a mutated mouse phenotype with a short, blunt-ended tail. The T-box DNA-binding domain is 173-185 amino acids in length, and demonstrates strong evolutionary conservation across vertebrate species. Seven mouse T-box genes have been identified: Tbx1-Tbx6 and Tbr-1. Tbx1 gene expression has been studied by RTPCR and in situ hybridization (ISH) throughout murine embryonic development; high expression levels correspond with cranial neural crest cell migration (embryonic days 8.5

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SPECIFICATIONS

Catalog Number

T1848-24

Size

100ug

Applications

IP, WB

Hosts

Rabbit

Reactivities

Mouse

Form

Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.

P Type

Pab

Purity

Purified by epitope affinity chromatography.

Isotype

IgG

References

1. Bollag RJ, et al. Nat Genet 7:383-389, 1994. 2. Bulfone A, et al. Neuron 15:63-78, 1995. 3. Chapman DL, et al. Developmental Dynamics 206:379-390, 1996. 4. Chieffo C, et al. Genomics 43:267-277, 1997. 5. Lindsay EA, et al. Nature 410:97-101, 2001. 6. Jerome LA, Papaioannou VE. Nat Genet 27(3):286-291, 2001. 7. Epstein JA. Trends Genet 17(10):S13-17, 2001. 8. Funke B, et al. Hum Mol Genet 10(22):2549-2556, 2001. 9. Vitelli F, et al. Hum Mol Genet 11(8):915-922, 2002.

Additional Info

Recognizes mouse T-box 1 protein. On Western blots, a ~50kD band is identified in mouse testis, lung, and skeletal muscle homogenates. In mouse testis, an additional band at ~40kD, which may represent an isoform of Tbox 1, is also identified. Reactivity has been confirmed with mouse testis, lung, and skeletal muscle tissue homogenates. Species sequence homology: three isoforms (A, B, C) of human T-box 1: 98%.

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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