TAAR1 (Trace Amine-associated Receptor 1, TaR-1, Trace Amine Receptor 1, TA1, TAR1, TRAR1)

TAAR1 is a 339aa novel membrane protein belonging to the G protein-coupled receptor family and is activated by a broad range of monoamines and amphetamine-related psychostimulants (biogenic amines). It has two N-glycosylation sites at its N-terminus and several potential protein kinase sites at its C terminus, including two serines and a single disulfide bridge. It shows lower cAMP accumulation in response to octopamine, tryptamine, dopamine and unresponsive to the classical biogenic amines norepinephrine, serotonin, and histamine. It is also known to have a chemosensory function distinct from odorant receptors and is involved in functional regulation ofDT and is a potentially important target for therapeutics for methamphetamine addiction. Recent studies demonstrated wide distribution of TAAR1 in brain.\n\nApplications:\nSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1-3ug/ml\nImmunohistochemistry (paraffin): 10ug/ml\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nHuman and rat brain lysate\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

T8170-01C4

Size

100ug

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.

P Type

Pab

Purity

Purified by Protein G affinity Chromatography.

Isotype

IgG

References

1. Liberles, SD. et al. Nature. 442:645-650 (2006). 2. Lindemann, L. et al. Genomics. 85:372-385 (2005). 3. Xie, Z. et al. J. Pharmacol. Exp. Ther. 321:128-136 (2007).

Additional Info

Recognizes human TAAR1. Species Crossreactivity: chimpanzee, rhesus monkey. Species sequence homology: rat.