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TAAR1 (Trace Amine-associated Receptor 1, TaR-1, Trace Amine Receptor 1, TA1, TAR1, TRAR1)

TAAR1 (Trace Amine-associated Receptor 1, TaR-1, Trace Amine Receptor 1, TA1, TAR1, TRAR1)

Cat no: T8170-01C4

Supplier: United States Biological
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TAAR1 is a 339aa novel membrane protein belonging to the G protein-coupled receptor family and is activated by a broad range of monoamines and amphetamine-related psychostimulants (biogenic amines). It has two N-glycosylation sites at its N-terminus and several potential protein kinase sites at its C terminus, including two serines and a single disulfide bridge. It shows lower cAMP accumulation in response to octopamine, tryptamine, dopamine and unresponsive to the classical biogenic amines norepinephrine, serotonin, and histamine. It is also known to have a chemosensory function distinct from odorant receptors and is involved in functional regulation ofDT and is a potentially important target for therapeutics for methamphetamine addiction. Recent studies demonstrated wide distribution of TAAR1 in brain. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1-3ug/ml Immunohistochemistry (paraffin): 10ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human and rat brain lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T8170-01C4
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity Chromatography.
References: 1. Liberles, SD. et al. Nature. 442:645-650 (2006). 2. Lindemann, L. et al. Genomics. 85:372-385 (2005). 3. Xie, Z. et al. J. Pharmacol. Exp. Ther. 321:128-136 (2007).
Additional info: Recognizes human TAAR1. Species Crossreactivity: chimpanzee, rhesus monkey. Species sequence homology: rat.

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