TACI, NT (Tumor Necrosis Factor Receptor Superfamily Member 13B, Transmembrane Activator and CAML Interactor, CD267, TNFRSF13B)

Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/ TALL-1/THANK/zTNF4 and April/TALL- 2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non-immunological cell growth. Three receptors, BCMA, TACI, and BAFF-R, for BAFF and April were recently identified. TACI, like BCMA, binds BAFF and April. TACI and its ligands regulate humoral immune responses, activate NF-kB and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.\n\nApplications:\nSuitable for use in ELISA, Western Blot and Immunocytochemistry. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 2-5ug/ml\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

T0294-01Q

Size

50ug

Applications

ELISA, ICC, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, 0.02% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Moore, PA. et al. Science 285, 260 (1999). 2. Schneider, P. et al. J. Exp. Med. 189, 1747 (1999). 3. Shu, HB. et al. J. Leukoc. Biol. 65, 680 (1999). 4. Mukhopadhyay, A. et al. J. Biol. Chem. 274, 15978 (1999). 5. Hahne, M. et al.J. Exp. Med. 188, 1185 (1998). 6. Gross, JA. et al. Nature 404, 995 (2000). 7. Thompson, JS. et al. Science 293, 2108 (2001). 8. Von Bulow, GU. et al. Science 278, 138 (1997).

Additional Info

Recognizes human TACI.