Supplier:
Alomone Labs Ltd.Cat no: T-800
TaiCatoxin
TaiCatoxin is isolated fromпїЅOxyuranus s.scutellatusпїЅsnake venom, by modification of the procedure of Possani and purified to homogeneity.
Taicatoxin was originally shown to be a specific and reversible blocker of high voltage activated Ca2+пїЅchannels in guinea pig and rat ventricular myocytes (probably Cav1.2). The IC50пїЅis voltage dependent decreasing from 500 nM at holding potential =-80 mV to 10 nM at holding potential = -30mV, indicating preference of block of the inactivated state of the channels.
However, another report shows that 50 nM Taicatoxin completely blocked SKcaпїЅapamin-sensitive channel.in chromaffin cells. Electrophysiological recordings were used to monitor Ca2+пїЅcurrents or action potential parameters from isolated myocytes and from chromaffin cells.
In addition, TaiCatoxin was used to displaceпїЅ125I-Apamin binding in rat brain synaptosomes.
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SPECIFICATIONS
Catalog Number
T-800
Size
0.1 mg
Purity
>97%
Concentration
50-500 nM.
Shipping Temp
Room Temperature
Molecular Weight
52000 da
SUPPLIER INFO
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