Tamm-Horsfall Glycoprotein (Uromucoid, THgp, THP, Uromodulin, UMOD) (Biotin) (BSA, Azide & Glycerol free)

Tamm-Horsfall glycoprotein (Uromucoid, THgp, Uromodulin, UMOD), which is synthesized by renal tubular cells, is the most abundant protein in normal human urine. Although its physiological function remains unclear, it has been proposed that Uromucoid, THgp, Uromodulin, UMOD may act as a defence factor against urinary tract infections by inhibiting the binding of S- and P-fimbriated Escherichia coli to renal epithelial cells. Because Uromucoid, THgp, Uromodulin, UMOD-related proteins are also found in the superficial layers of the oral mucosa, Uromucoid, THgp, Uromodulin, UMOD may interfere with the cytoadherence of pathogenic bacteria that colonize mucosal surfaces other than those of the urogenital tract. It has been shown that Uromucoid, THgp, Uromodulin, UMOD binds to virulent Bordetella pertussis and reduces its adherence to both renal and pulmonary epithelial cells. This cytoadherence inhibitory effect was not observed with a B. pertussis mutant lacking the pertussis toxin (PTX) operon, and was dependent on the direct interaction of Uromucoid, THgp, Uromodulin, UMOD with the S2 subunit within the PTX B oligomer. \n\nApplications: \nSuitable for use in IEP, RID, Double Diffusion and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

T0850B1

Size

1ml

Applications

IHC

Hosts

Sheep

Reactivities

Hum

Conjugates

Biotin

Form

Supplied as a liquid in PBS, pH 7.2. No preservative added. No stabilizing proteins added. Glycerol free. Labeled with Biotin.

P Type

Pab

Purity

Purified

Isotype

IgG

References

I. Tamm and F.L Horsfall. Proc. Soc. Exp. Biol. Med. 74, 108-114 (1950). 2. Kidney Int. 16, 279-289 (1979). 3. Science 236, 83-87 (1987). 4. Science 237, 1479-1484 (1987).\nGeneral References::\n1. Microbiology. 2002 Apr;148(Pt 4):1193-201. Interaction of human Tamm-Horsfall glycoprotein with Bordetella pertussis toxin. Menozzi FD, Debrie AS, Tissier JP, Locht C, Pethe K, Raze D.

Additional Info

Recognizes Tamm-Horsfall Glycoprotein. One arc by 2D-IEP against Tamm-Horsfall glycoprotein (1mg/ml). No precipitin line by IEP against normal human plasma. Identity verified by double immunodiffusion.