TAR DNA Binding Protein 43 (TARDBP, TDP-43, TDP43)

Supplier:

United States Biological

Cat no: T1019-47A

TAR DNA Binding Protein 43 (TARDBP, TDP-43, TDP43)

HIV-1, the viral cause of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression, by the transactivator Tat, is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. TARDBP is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. Recently it has been shown that TDP-43 accumulates abnormally in post-mortem brain tissue from individuals diagnosed with both ALS (Amyotrophic Lateral Sclerosis) and FTD (Frontal Temporal Dementia). This observation provides a long sought connection between two disease that often over-lap clinically.\n\nApplications: \nSuitable for use in Western Blot, Immunohistochemistry and Immunofluorescence/Immunocytochemistry. Other applications not tested.\n\nRecommended Dilutions:\nWestern Blot: 0.5-2ug/ml\nImmunofluorescence/Immunocytochemistry: 1:100-1:1000. A nuclear signal is present in MCF-7 cells.\nOptimal dilutions to be determined by the researcher.\n\nPositive Control: \nHela Whole Cell Extract\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

T1019-47A

Size

100ul

Applications

ICC, IF, IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Ch/Bird, NHP, Xen/Amph

Form

Supplied as a liquid in Tris-glycine, 150mM sodium chloride, 0.05% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Geser F, et al. Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosis. Arch Neurol. 2008 May;65(5):636-41. 2. Wegorzewska I, Bell S, Cairns NJ, et al. TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18809-14.

Additional Info

Recognizes human TAR DNA Binding Protein 43 at ~45kD. Species Crossreactivity: primate, mouse, chicken, Xenopus, zebrafish.

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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