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TAR DNA Binding Protein (TARDBP) Recombinant, Human

Cat no: T1019-40

TAR DNA Binding Protein (TARDBP) Recombinant, Human

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. This protein is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. \n\nPrimary Sequence (aa): 1-414\n\nTag/Fusion Partner: His tag at N-terminus\n\nApplications: Suitable for as a standard in ELISA and Western Blot Other applications have not been tested.\n\nQuality Control: \nSDS-PAGE at ~30kD \n\nStorage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70 degrees C. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.\n\nImportant note: This recombinant enzyme has NOT been tested with regard to biological activity.

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SPECIFICATIONS

Catalog Number

T1019-40

Size

50ug

Reactivities

Hum

Form

Supplied as a liquid in PBS.

Purity

~90% Highly purified

References

1. Ou, S.H. et al., J Virology. 69: 3584-3596

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