Tau Antibody

Cat no: 251800

Supplier: ABBIOTEC

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Description
Additional Information

Microtubule-associated protein tau (tau) promotes microtubule assembly and stability, and is involved in the establishment and maintenance of neuronal polarity. The C-terminus binds a, Xenopus/Amphibian,onal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. A, Xenopus/Amphibian,onal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms play a role in its stabilization. In Alzheimer disease, the neuronal cytoskeleton in the brain is progressively disrupted and replaced by tangles of paired helical filaments (PHF) and straight filaments,Mouse,ainly composed of hyperphosphorylated forms of tau (PHF-tau or AD P-tau).

Catalogue number:	251800
Reactivities:	Human, Mouse, Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	P10636
Antigen:	Bovine microtubule-associated proteins (MAPs).
Format:	Each vial contains 0.1 mg IgG1 in 0.1 ml (1 mg/ml) of PBS pH7.4, 2%BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Mouse Monoclonal Antibody
Isotype:	Mouse IgG1
Additional info:	Tau; Microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; MAPT; MAPTL; MTBT1