Tau (Microtubule-associated Protein tau, MAPT, DDPAC, FTDP-17, FLJ31424, MAPTL, MGC138549, MSTD, MTBT1, MTBT2, Neurofibrillary Tangle Protein, Paired Helical Filament-tau, PHF-tau, PPND)

Tau is the major microtubule-associated protein in neuronal axons that regulates microtubule stability, neurite outgrowth, and other microtubule -dependent functions. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Six tau isoforms are produced in adult Human brain by alternative mRNA splicing from a single gene. Inclusion of a 31 amino acid repeat encoded by exon 10 of the tau gene gives rise to the three isoforms with four microtubule-binding repeats each. The other three isoforms have three repeats each. Abundant neurofibrillary lesions made of the protein constitute a defining neuropathological characteristic of Alzheimer's disease. Filamentous tau protein deposits are also the defining characteristic of other neurodegenerative diseases, many of which are frontotemporal dementias or movement disorders, such as Pick's disease, progressive supranuclear palsy, and corticobasal degeneration.\n\nApplications:\nSuitable for use in Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nImmunohistochemistry (paraffin): 1:50-1:100\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nAlzheimer

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SPECIFICATIONS

Catalog Number

T1030-01R

Size

500ul

Applications

IHC

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in 0.05% sodium azide.

P Type

Pab

Purity

Serum

Isotype

IgG

References

1. Brion et al. Neuroscience 2: 89, 1990. 2. Butner et al. J Cell Biol 115: 717, 1991. 3. Goedert et al. Proc Natl Acad Sci 85: 4051, 1998. 4. Michel et al. Annals of the New York Academy of Sciences 920: 74, 2000. 5. Mukrasch et al. J Biol Chem 282:12230, 2007.

Additional Info

Recognizes human Tau.