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Tau (Microtubule-associated Protein Tau, Neurofibrillary Tangle Protein, Paired Helical Filament-tau, PHF-tau, MAPT, MAPTL, MTBT1)

Cat no: T1030-11N

Tau (Microtubule-associated Protein Tau, Neurofibrillary Tangle Protein, Paired Helical Filament-tau, PHF-tau, MAPT, MAPTL, MTBT1)

Tau is a collection of microtubule-associated proteins that is involved in microtubule assembly and stabilization. In adult human brain, 6 isoforms ranging between 352 and 441aa in length are produced as a result of alternative RNA splicing. The expression of tau isoforms is developmentally regulated, as only the smallest tau polypeptide is expressed in fetal brain. Hyperphosphorylated Tau is the major component of the paired helical filament of Alzheimer

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SPECIFICATIONS

Catalog Number

T1030-11N

Size

25ug

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat, Can, NHP

Form

Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Billingsley, M. et al. Biochem J 323, 577 (1997). 2. Geodert, M. et al. EMBO J 8, 393 (1989). 3. Goedert, M. et al. Neuron 3, 519 (1989). 4. Cleveland, D. et al. J Mol Biol 116, 207 (1977).

Additional Info

Recognizes human Tau. Species Crossreactivity: mouse at 52-68kD, rat, canine and monkey.

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