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Tau, phosphorylated (Ser404) (Tau Protein, Microtubule-associated Protein, MAP)

Cat no: T1032-70

Tau, phosphorylated (Ser404) (Tau Protein, Microtubule-associated Protein, MAP)

Tau is a neuronal microtubule-associated protein found predominantly on axons that functions to promote tubulin polymerization and stabilize microtubules. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer

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SPECIFICATIONS

Catalog Number

T1032-70

Size

100ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS (without Mg2+ and Ca2+), 1mg/ml BSA (IgG, protease free), pH 7.2, 0.1% sodium azide, 50% glycerol. Also available wthout azide, BSA, glycerol. See T1032-70A.

P Type

Pab

Purity

Purified from by epitope-affinity chromatography.

Isotype

IgG

References

1. Liu, F., et al. (2002) Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta. FEBS Letters 530(1-3):209-214 (cites the use of 44-732, 44-734, 44-736, 44-738, 44-740, 44-742, 44-744, 44-746, 44-750, 44-752, 44-758, 44-758 and 44-760).\n\n2. Jenkins, S.M., et al. (2000) Modulation of tau phosphorylation and intracellular localization by cellular stress. Biochem. J. 345(Pt 2):263-270.\n\n3. Mandelkow, E. (1999) Alzheimer's disease. The tangled tale of tau. Nature 402(6762):588-589. Goedert, M. (1999) Alzheimer's disease. Pinning down phosphorylated tau. Nature. 399(6738):739- 740.\n\n4. Davis, P.K. and G.V. Johnson (1999) The microtubule binding of Tau and high molecular weight tau in apoptotic PC12 cells is impaired because of altered phosphorylation. J. Biol. Chem. 274(50):35686-35692.\n\n5. Sontag, E., et al. (1999) Molecular interactions among protein phosphatase 2A, tau, and microtubules. Implications for the regulation of tau phosphorylation and the development of tauopathies. J. Biol. Chem. 274(36):25490-25498.\n\n6. Wang, J.Z., et al. (1998) Tau is phosphorylated by GSK-3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A-kinase FEBS Lett. 436(1):28-34.

Additional Info

Recognizes human tau. Species sequence homology: Mouse and rat 100%.

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