Tau (Ser416) Antibody

Cat no: 252587

Supplier: ABBIOTEC

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Tau protein promotes microtubule assembly and stability. Tau is also involved in the establishment and maintenance of neural polarity. The C-terminus domain of Tau binds to a, Xenopus/Amphibian,onal microtubules whereas the N-terminus domain binds to neural plasma membrane components, therefore suggesting that Tau protein functions as a linker between the two. A, Xenopus/Amphibian,onal polarity is predetermined by tau localization in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. PNS-tau is e, Xenopus/Amphibian,pressed in the peripheral nervous system whereas the other isoforms are e, Xenopus/Amphibian,pressed in the central nervous system. Defects in Tau protein are a cause of dementia,Porcinearkinsonism and Alzheimer disease. It has been well documented that hyperphosphorylated tau is a major component of paired helical filaments in AD brain. Serine 416 has been demonstrated to be a major phosphorylation site in vitro by CaM kinase II.

Catalogue number:	252587
Reactivities:	Mouse, Bovine, Rabbit
Applications:	Western Blot
Size:	0.1 ml
Accession:	P19332
Antigen:	KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser416 of rat Tau.
Format:	Each vial contains 0.1 ml IgG in HEPES pH7.5, 150 mM NaCl, 0.01% BSA and 50% glycerol. Antibody was purified by immunogen affinity chromatography.
P type:	Rabbit Polyclonal Antibody,Porcinehosphospecific Antibody
Isotype:	Rabbit IgG
Additional info:	Microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau; MAPT; MAPTL; MTBT1, TAU

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Tau (Ser416) Antibody

Cat no: 252587

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