Tau (Tau Protein, Neurofibrillary Tangle Protein, Paired Helical Filament-tau, PHF-tau, MAPT, MTBT1)

Tau protein promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. Tau is expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system. Four-repeat (type II) tau is expressed in an adult-specific manner and is not found in fetal brain, whereas three-repeat (type I) tau is found in both adult and fetal brain. \nThe tau/MAP repeat binds to tubulin. In Alzheimer

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SPECIFICATIONS

Catalog Number

T1030-05

Size

100ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum, Prc

Form

Supplied as a lyophilized powder. Reconstitute with 100ul sterile ddH2O.

P Type

Pab

Purity

Serum

Isotype

IgG

References

1. Goedert, M., et al., Proc. Natl. Acad. Sci. U.S.A. 85: 4051-4055 (1988). 2. Goedert, M., et al., Neuron 3: 519-526 (1989). 3. Lee, G., et al., Neuron 2: 1615-1624 (1989). 4. Andreadis, A., et al., Biochemistry 31: 10,626-10,633 (1992). 5. Jakes, R., et al., EMBO J. 10: 2725-2729 (1991). 6. Cripps, D., et al., J. Biol. Chem. 281: 10,825-10,838 (2006). 7. Maas, T., et al., J. Biol. Chem. 275: 15,733-15,740 (2000). 8. Nacharaju, P., et al., J. Neurochem. 69: 1709-1719 (1997). 9. Wintjens, R., et al., J. Biol. Chem. 276: 25,150-25,156 (2001). 10. Oliva, R., et al., Ann. Neurol. 55: 448-449 (2004).

Additional Info

Recognizes human Microtubule-associated Tau proteins. Detects the purified recombinant Tau expressed in E. coli as well as a number of Tau isoforms in porcine cytosol. Species Crossreactivity: porcine.