TAZ Peptide

Cat no: BS5954P

Supplier: Bioworld Technology, Inc.

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The transcriptional co-activator with PDZ-binding motif (TAZ) is a 14-3-3-binding molecule. The highly conserved and ubiquitously expressed 14-3-3 proteins regulate differentiation, cell cycle progression and apoptosis by binding intracellular phosphoproteins involved in signal transduction. TAZ may link events at the plasma membrane and cytosketeton to nuclear transcription in a manner that can be regulated by 14-3-3. TAZ shares homology with the WW domain of Yes-associated protein (YAP) and functions as a transcriptional co-activator by binding to the PPXY motif present on transcription factors. TAZ recognizes immunoreactive protein bands in lysates from MDCK, NIH-3T3 and 293T cells. In addition, COS7, Hep G2, CHO and HeLa cells express endogenous TAZ. 14-3-3 binding requires TAZ phosphorylation on a single Serine 89 residue, resulting in the inhibition of TAZ transcriptional co-activation through 14-3-3-mediated nuclear export.

Catalogue number:	BS5954P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	Q16635
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide TAZ. (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	Tafazzin; Protein G4.5; EFE2; G4.5
Additional info:	This peptide can be used with studies using BS5954 TAZ pAb.

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TAZ Peptide

Cat no: BS5954P

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